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Jak2 (V617F)
Sample: Blood
While JAK2 mutations are rare, they can cause various bone marrow disorders. 1 These are known as myeloproliferative neoplasms (MPNs), where the bone marrow produces too many blood cells
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The JAK2 V617F mutation is an acquired, somatic mutation present in the majority of patients with myeloproliferative cancer (myeloproliferative neoplasms) i.e. nearly 100% of patients with polycythemia vera and in about 50% of patients with essential thrombocytosis and primary myelofibrosis
What does JAK2 V617F positive mean?
The JAK2 V617F mutation is an acquired, somatic mutation present in the majority of patients with myeloproliferative cancer (myeloproliferative neoplasms) i.e. nearly 100% of patients with polycythemia vera and in about 50% of patients with essential thrombocytosis and primary myelofibrosis
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